Active Grants

    Alcohol Research

  • Genome-wide Identification of miRNAs Associated with Alcoholism Endophenotypes

    Role: PI; NIH/NIAAA R01 AA021131 2013-2018

    The goals of this project are 1) to perform high-throughput miRNA brain expression profiling in a large panel of RI mice and 2) to identify miRNAs and respective target mRNA expressed in the brain associated with the predisposition to alcoholism endophenotypes.

    Chronic Obstructive Pulmonary Disease

  • Omics Data Integration to Identify Disease Pathways in COPD

    Role: Multi-PI (Kechris, Bowler, Banaei-Kashani); NIH/NHLBI R21 HL140376 2017-2019

    This project will integrate -omics datasets using machine learning to identify pathways that can serve as novel diagnostic and therapeutic targets for chronic obstructive pulmonary disease, and for molecular subtyping of this complex and heterogeneous disease.

    Diabetes

  • Epigenetic Marks of In Utero Exposure to Gestational Diabetes

    Role: Multi-PI (Dabelea, Yang, Kechris); NIH/NIDDK R01 DK100340 2014-2018

    The overarching hypothesis of this project is that exposure to maternal GDM in utero will be associated with changes in DNA methylation patterns of key genes/pathways in the offspring and that these epigenetic changes will mediate the association between in utero exposure and childhood/adolescence adiposity-related outcomes.